![]() ![]() CSF culture has a turnaround time (TAT) of 24-48 hours and TATs for standard PCR tests can range from a few hours to several days, depending on whether the test is performed in-house or has to be shipped to a reference lab. Benefits of a rapid turnaround timeĭue to the potential severity of CNS disease, early and effective treatment is critical to reducing morbidity and mortality however, many current diagnostic methodologies are technically cumbersome or time-consuming to perform. The addition of this type of panel-based syndromic testing to CNS disease allows detection of a wide range of pathogens in a clinically actionable time frame and has demonstrated high diagnostic value with other infectious disease syndromes. In addition to these single-target viral detection assays, a rapid commercial multiplex PCR test for the detection of 14 pathogens received FDA clearance for use as an aid to diagnosis of meningitis or encephalitis in October 2015. In some cases, serological testing may be more appropriate for suspected arbovirus infections since immunocompetent patients may not have these viruses in their CSF at the time of presentation. In contrast to bacterial detection, PCR has become the gold standard for detecting viruses associated with aseptic meningitis or encephalitis. Other methods for detection and identification of bacterial pathogens such as direct antigen testing or polymerase chain reaction (PCR) are not yet commonly used as first line diagnostics, but have recognised value in patients with clinical findings consistent with a bacterial CNS infection who have negative Gram stain and culture results. The standard method for diagnosis of bacterial meningitis is Gram stain and CSF culture. These differential indicators are useful to aid in diagnosis, but because of overlap between etiologies, they are not sufficient to guide targeted therapy. Clinical findings such as cell count, glucose and protein concentrations can provide clues regarding infection. For cases of acute meningitis or encephalitis, CSF is obtained via lumbar puncture (LP). Andrew Hemmert and Jeremy Gilbreath of BioFire Diagnostics review the current landscape for diagnostic testing of cerebrospinal fluid (CSF) in acute CNS infections.Īnalysis of patient CSF is crucial for diagnosis and management of CNS infection. ![]() As a result, obtaining a rapid and accurate diagnosis is important for proper patient management. Each meeting space also includes active room scheduling via the Crestron FusionRV Enterprise Management Platform.Given the similarity in symptomology, it is often difficult to distinguish bacterial and viral infections of the central nervous system based on clinical presentation alone.Crestron DM (DigitalMedia) serves as the backbone for this deployment.4K LED displays placed throughout the facility.Christie Digital projectors into training rooms.audio-visual services in forty-five locations throughout the building, including a mix of small, medium, and large conference rooms and a large training room. ![]()
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